Severe symptoms can cause contractures. Contractures are the stiffening of muscles, skin, or connective tissue. Another severe symptom is the loss of hand function. Dupuytren’s disease generally progresses slowly, but progression is unpredictable. The onset of Dupuytren’s disease is very slow. Both hands may be affected but usually one hand is more affected than the other.
You may notice a small tender lump in the palm of your hand. The tenderness will go away as Dupuytren’s disease typically is not painful. Over time, tough cords may form beneath your skin. The thickened tissue may cause your fingers to bend inward toward your palm. Your ring finger and little finger are affected most often. You may have difficulty straightening your fingers.
The progression of Dupuytren’s disease is unpredictable. For some, the condition may consist of a lump or thickening of the tissue. Other people may experience severe symptoms, including contractures and loss of hand function.